Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks

Neurotransmitters drive combinatorial multistate postsynaptic density networks.

The mammalian postsynaptic density (PSD) comprises a complex collection of approximately 1100 proteins. Despite extensive knowledge of individual proteins, the overall organization of the PSD is poorly understood. Here, we define maps of molecular circuitry within the PSD based on phosphorylation of postsynaptic proteins. Activation of a single neurotransmitter receptor, the N-methyl-D-aspartat...

Enlightening the Postsynaptic Density

1974; Landis et al., 1974; Peters et al., 1991). Related structures are also found at the neuromuscular junction The postsynaptic density (PSD) is a specialization of the (Sanes, 1997). Major morphological variants of type 1 cytoskeleton at the synaptic junction. It lies adjacent to synapses include axodendritic synaptic junctions formed the cytoplasmic face of the postsynaptic membrane, in on ...

The postsynaptic density

when fossil skeletons and eggs from other countries are sold at auction, they've been illegally obtained. Oh, they have papers, but they aren't legitimate as far as their governments are concerned. If the US and other countries prohibited the import of such fossils, as well as the export of their own fossils, much of this problem would disappear. A related problem arises when scientists try to ...

Proteins of the Postsynaptic Density

An analysis was made of the protein composition of a fraction of postsynaptic densities (PSDs) prepared from rat brain. Protein makes up 90% of the material in the PSD fraction. Two major polypeptide fractions are present, based on sodium dodecyl sulfate polyacrylamide gel electrophoresis. The major polypeptide fraction has a molecular weight of 53,000, makes up about 45% of the PSD protein, an...

Iterated combinatorial density theorems